E-Posters

introduction / background

Scabies is one of the commonest dermatological diseases that has global health burden. Current treatment with ivermectin (IVM) is insufficient and potential drug resistance was noticed. Moxidectin(MOX), with a better pharmacological profile may be a promising alternative.

Objectives

This work aims to evaluate the efficacy of moxidectin in vitro and in vivo against Sarcoptes scabiei compared with ivermectin.

Materials & Methods

For in vivo assessment, twenty rabbits infected with Sarcoptes scabiei were divided into three groups: untreated, moxidectin-treated (0.3 mg/kg once) and ivermectin-treated (0.3 mg/kg once).Treatment efficacies were evaluated by clinical assessment, parasitological evaluation, histopathological examination and immunohistochemical study for CD3 T cells in skin samples for 21 days post treatment.

Results

Moxidectin showed high efficacy(100%) killing mites when used in both concentrations (50 μg/m, 100 μg/ml) in the in vitro assessment. Regarding the in vivo study, on day 14 post-treatment, all MOX-treated rabbits were mite-free with full clinical cure by the end of the study (D21) showing (100%)reduction of mite count. Marked improvement in the epidermis with absence of mites in skin samples were shown. Poor clinical and parasitological improvements were noted in the ivermectin-treated rabbits, when given as a single dose. The peak percentage reduction of mite count was recorded in the 2nd week (60.67%) with progressive increase in lesions and mite count in the 3rd week post-treatment.

Conculsion

Data demonstrated that single-dose of MOX was more effective than IVM, supporting MOX as a valuable therapeutic approach for scabies therapy.

References

Currie, B.J. and McCarthy, J.S. 2010. Permethrin and ivermectin for scabies. N. Engl. J. Med., 362: 717-725. Deger, T.B. and Ural, K. 2013. Comparable efficacy of topical eprinomectin and permethrin for treatment of sarcoptic mange in dogs. Vet. Arhiv., 83 : 393-402.

acknowledgement / Contact

© 2021. Tanta University. All right reserved.