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Trichinellosis is a cosmopolitan zoonotic parasitic disease that causes a harmful inflammatory response. Corticosteroids are used for anti-inflammatory treatment but causes immune-suppression.

The present study evaluated the anti-inflammatory effect of resiniferatoxin (RTX), a TRPV1 receptor agonist as an adjuvant therapy with albendazole on the early and late stages of experimental trichinellosis in comparison with cortisone.

The effect of RTX was evaluated by determination of the adult worm count in the intestine, the total larval count in the skeletal muscles, the viability of T. spiralis larvae by trypan blue stain and the determination of the serum level of IFN-γ and iNOS by ELISA.

Our results showed that treatment with (albendazole and RTX) significantly decreased the adult count, the total larval count and the inflammation in both the intestinal and the musclar phases in comparison with other groups. In addition, RTX decreased the serum levels of IFN-γ and iNOS.

We concluded that RTX has valuable anti-inflammatory and immuno-modulatory effects against T. spiralis infection and is beneficial for the treatment of trichinellosis as compared to cortisone.

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